Spontaneous Regression of Intravascular Large B-Cell Lymphoma and Apoptosis of Lymphoma Cells: A Case Report

Tsutomu Takahashi; Fumiyoshi Ikejiri; Saki Takami; Takahiro Okada; Satoshi Kumanomidou; Koji Adachi; Jo Yumi; Chie Onishi; Koshi Kawakami; Ichiro Moriyama; Masaya Inoue; Takaaki Miyake; Junko Tanaka; Riruke Maruyama; Junji Suzumiya

doi:10.3960/jslrt.55.151

Case Study

Spontaneous Regression of Intravascular Large B-Cell Lymphoma and Apoptosis of Lymphoma Cells: A Case Report

Tsutomu Takahashi, Fumiyoshi Ikejiri, Saki Takami, Takahiro Okada, Satoshi Kumanomidou, Koji Adachi, Jo Yumi, Chie Onishi, Koshi Kawakami, Ichiro Moriyama, Masaya Inoue, Takaaki Miyake, Junko Tanaka, Riruke Maruyama, Junji Suzumiya

Author information

Tsutomu Takahashi
Department of Oncology/Hematology, Shimane　University Hospital
Fumiyoshi Ikejiri
Department of Oncology/Hematology, Shimane　University Hospital
Saki Takami
Department of Oncology/Hematology, Shimane　University Hospital
Takahiro Okada
Department of Oncology/Hematology, Shimane　University Hospital
Satoshi Kumanomidou
Department of Oncology/Hematology, Shimane　University Hospital
Koji Adachi
Department of Oncology/Hematology, Shimane　University Hospital
Jo Yumi
Department of Oncology/Hematology, Shimane　University Hospital
Chie Onishi
Department of Oncology/Hematology, Shimane　University Hospital
Koshi Kawakami
Department of Oncology/Hematology, Shimane　University Hospital
Ichiro Moriyama
Department of Oncology/Hematology, Shimane　University Hospital
Masaya Inoue
Department of Oncology/Hematology, Shimane　University Hospital
Takaaki Miyake
Department of Oncology/Hematology, Shimane　University Hospital
Junko Tanaka
Department of Oncology/Hematology, Shimane　University Hospital
Riruke Maruyama
Department of Pathology, Shimane University Hospital
Junji Suzumiya
Department of Oncology/Hematology, Shimane　University Hospital

Keywords: spontaneous regression, intravascular large B-cell lymphoma, apoptosis

JOURNAL FREE ACCESS

2015 Volume 55 Issue 3 Pages 151-156

DOI https://doi.org/10.3960/jslrt.55.151

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Abstract

　 A 61-year-old Japanese woman presented with hemophagocytic syndrome (HPS) and suffered from intravascular large B-cell lymphoma (IVLBCL). After a few days of supportive care, her condition improved without any anti-cancer drugs or steroids. She experienced recurrences of HPS at 15 mon and 21 mon after first presentation, but lymphoma cells were not observed. Relapse of IVLBCL with pulmonary involvement occurred 27 mon after first presentation. She underwent R-CHOP therapy followed by autologous stem cell transplantation. She is currently alive and without lymphoma. Immunostaining by anti-ssDNA suggested that spontaneous regression may have been due to apoptosis of the lymphoma cells. [J Clin Exp Hematop 55(3) : 151-156, 2015]

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