2022 Volume 64 Issue 6 Pages 1221-1227
A 72-year-old woman was diagnosed with acute myeloid leukemia (AML) and received chemotherapy, 1 year prior to presentation. She was unresponsive to treatment and showed FLT3-ITD and NPM1 mutations; therefore, gilteritinib therapy was initiated at the Department of Hematology of our hospital. She developed generalized fatigue one month before her visit and was admitted to the Hematology Department for evaluation of anorexia and nausea. Esophagogastroduodenoscopy (EGD) revealed diffuse white flat elevated lesions in the gastric body. Histopathological evaluation showed atypical cell infiltration and destruction of the glandular structure of the gastric mucosal surface. Immunohistochemical analysis showed blast cell proliferation similar to the findings on bone marrow aspiration performed previously. Therefore, the patient was diagnosed with gastric infiltration of leukemia cells. EGD performed after intensification of chemotherapy revealed persistent white flat elevated lesions, although these were fewer and showed improvement compared with the previous EGD. We report a case of acute myeloid leukemia gastric infiltration with multiple white flat elevated lesions in the gastric body.
