2023 Volume 65 Issue 8 Pages 1322-1326
A 78-year-old man underwent a routine upper gastrointestinal endoscopy, which revealed a depressed lesion of 15mm at the lesser curvature of the gastric antrum. Histopathological diagnosis of the biopsy specimen revealed a well-differentiated adenocarcinoma. No obvious metastasis was detected. An ESD was performed. Histopathological examination of the ESD-acquired specimen revealed an intramucosal lesion with negative surgical margins and no lymphovascular invasion, indicating complete endoscopic resection. The lesion consisted of cells with clear cytoplasm, and immunostaining revealed positivity for AFP, glypican-3, and SALL4. Therefore, the patient was diagnosed with AFP-producing gastric cancer. Herein, we have reported a rare case of AFP-producing early gastric cancer that was completely resected endoscopically.
