2023 Volume 65 Issue 9 Pages 1434-1440
A 56-year-old man was diagnosed with prerenal failure secondary to continuous severe diarrhea for one week. He received a large volume of fluid replacement therapy and was fasting for the management of suspected infectious enteritis. However, there was no improvement in both diarrhea and renal function. Stool culture tests showed no pathogenic bacterial growth, and the cause of the diarrhea remained unknown. CS revealed a diminished vascular pattern and crack-like mucosal grooves extending from the sigmoid colon to the rectum. Histopathological examination of random biopsy specimens obtained from different parts of the colon showed intraepithelial lymphocytic infiltration in the surface epithelium, leading to the diagnosis of lymphocytic colitis. Administration of cholestyramine improved diarrhea and renal function. Accurate detection of even minimal endoscopic findings and mucosal biopsy for histopathological evaluation are useful for the diagnosis of microscopic colitis, including lymphocytic colitis, in patients with chronic diarrhea of unknown cause.
