2025 Volume 67 Issue 5 Pages 1069-1075
In 2011, an 83-year-old woman was diagnosed with Sjögren syndrome and underwent anticoagulation therapy for atrial fibrillation. Because of anemia, she was referred to our Department of Gastroenterology in January 2023 for further examination. Upper gastrointestinal endoscopy revealed a 10-mm 0-Ⅱc-like faded lesion in the greater curvature of the lower gastric body; therefore, biopsy was performed. The following day, the patient revisited the hospital because of melena. Endoscopic hemostasis was performed to stop bleeding. Immunohistochemistry revealed transthyretin amyloidosis, suggesting that tissue fragility due to amyloid deposition and anticoagulant therapy caused bleeding.
