2026 Volume 68 Issue 8 Pages 1420-1429
EIS for esophageal varices has been widely performed in Japan due to its therapeutic efficacy. However, owing to its technical complexity and the risk of complications such as bleeding, the simpler approach of endoscopic variceal ligation (EVL) alone has become more prevalent. Endoscopic injection sclerotherapy with ligation (EISL), which combines EIS with EVL, is an effective treatment modality that enhances the therapeutic efficacy of EIS while reducing the procedural burden on the endoscopist. In this article, we provide a detailed description of EISL, including evaluation methods using EUS before and after EIS, to facilitate its practical implementation.