Abstract
Endoscopic direct and indirect methylene blue (MB) staining methods were done in 53 subjects aged 21-77 years, and the ability of making a diagnosis was compared on each method. Both indirect MB staining method and dyeing method using MB by Suzuki et al. were done in 9 cases of gastric cancer and 19 cases of gastric polyp within a week. The staining area and the grade in these lesions were compared on both method. Staining with indirect MB method was done twice in 44 cases within a month and the reproducibility of staining was evaluated. The following results were obtained; 1) The indirect MB staining method is superior on making an accurate endoscopic evaluation of the degree and the extent of intestinal metaplasia, and its reproducibility is good. Moreover, this method is simpler than a direct MB staining method. 2) There is no difference between indirect MB staining method and dyeing method in making a diagnosis of gastric cancer. The indirect MB staining method is superior to the dyeing method in the diagnosis of protruded lesions of the stomach.
