Abstract
Application of endoscope using hydrogen electrode enabled us to measure gastric submucosal blood flow without any surgery nor damage to the subjects. Gastric submucosal blood flow and its distribution between the antrum and corpus was measured in dogs under the influences of several agents known to affect gastric secretion. Resting submucosal perfusion was 75.3±13.5 ml per min per long of submucosa for the antrum and 47.3±12.7 ml per min per 100g of submucosa for the corpus. The effect of feeding on submucosal blood flow was studied and a remarkable increase of perfusion in the corpus with a little blood flow increase in the antrum was noted. Graded doses of AOC-tetrapeptide by cotinuous intravenous infusion stimulatedsubmucosal blood flow in the corpus and the antrum and increased the corpus/antrum perfusion ratio, except at the maximal dose. Secretin infused under no stimulation did not affect the blood flow but following gastrin stimulation decreased submucosal perfusion. Betazole hidrochloride increased blood flow in both parts, predominantly in the corpus. Epinephrine infusion increased perfusion, and norepinephrine infused continuously decreased resting and Histalog-stimulated submucosal perfusion, but single injection of both agents brought about a sudden increase of perfusion acompanied by a gradual decrease of blood flow. The present study lends further support to the validity of H2 gas clearance method using endoscope as measurement of gastric submucosal blood flow. It is further shown that redistribution of submucosal blood flow from the antrum to the corpus did not occur with AOC-tetrapeptide and Histalog stimulation.
