LAPAROSCOPIC EXAMINATION OF CHRONIC LIVER DISEASES

-POSSIBLE RELATIONSHIP BETWEEN PATCHY MARKING AND HEPATOCELLULAR CARCINOMA-

Abstract

To investigate the relationship between patchy marking and hepatocellular carcinoma (he. patoma), 103 cases of chronic liver diseases and 25 cases of hepatoma were examined. Patchy marking was obseved in 29.0% of total cases of chronic liver diseases. Moreover, patchy marking was seen in 47.8% of positive cases (30 cases) for liver cell dysplasia which has been focused as possible precancerous lesion, on the other hand it was also revealed in the incidence of 40.0% of hepatoma bearers. The incidence of HBsAg-or HBsAb-positive cases was 20.7% in patchy marking bearing cases. The elevation of serum α-fetoprotein over 200 mg/ml was seen in 37.9% of cases associated with patchy marking, while it was shown only in 12.5% of the cases without patchy marking. Liver cell dyspasia was highly seen in the cases of chronic liver diseases, bearing hill-shaped nodules. Regarding to the incidence of liver cell dysplasic and significantly increased α-fetoprotein level among the cases with patchy marking, it might be concluded that the patchy marking is very important factor to set up a concept of high risk group for the development of hepatoma in the cases with chronic liver diseases.