RELATIONSHIP BETWEEN THE ENDOSCOPIC TYPE OFTHE GLANDULAR BORDER BY CONGO RED TEST ANl THE SERUM PEPSINOGEN LEVELS BY RADIOIMMUNOASSAY. AND THE GASTRIC ACID-PEPSIN ANALYSES

Abstract

The relationship between the types classified endoscopically by the distribution of the glandular border at Congo red test during the panendoscopy examination, and the serum pepsinogen levels detected by the radioiinmunoassay method as previously reported (Clin. Chim. Acta 122 : 61 and 126 : 83, 1982) has been studied in 64 patients at Tokyo University Hospital. Fifty-seven patients of them received the gastric analyses on the other day. The results were obtained as follows: 1) The serum %PG I (group I pepsinogen level/group I pepsinogen level+group II pepsinogen level×100) dropped gradually from the C₀ -type (closed-type by the classification of the endoscopic glandular border) to 0₃ -type (open-type by the same classification), and the C₀ -type showed the statistically significant differences against C2 and O1-type with p<0.01, respectively, and against O₂ and O₃ -type with p<0.001, respectively, according to the Student's t-test. 2) The serum %PG I values are more useful than the serum group I pepsinogen (PG I) absolute levels or the examination of the gastric analyses when we want to know the degree and extent of the atrophy of the gastric mucosa. It is suggested that there is the possibility the %PG I be a tool for the so-called "serologic boipsy", which is claimed by Samloff and his collegues.