Abstract
A rare case of ulcerative colitis complicated by antibiotic-indnced peeudomembranous colitis and Basedow's disease was reported. Sixty-six-year-old woman with a history of a subtotal thyroidectomy at the age of forty-six complained of diarrhea of four-months' duration. Since antibiotics were given to the patient three weeks prior to admission and pseudomembranes were seen in the colon, a diagnosis of antibiotic-induced pseudomembranous colitis was made. Despite of administration of metronidazole and vancomycin altogether for nine weeks, colitis did not subsided completely. Thereafter treatment was shifted to Salazopyrin (P. O) and predonisolone enema which were very effective. This case was concluded as ulcerative colitis had been complicated by antibiotic-indnced pseudomembranous colitis because of the following reasons. 1) She had diarrhea and bloody stool and roentgenogram of barium enema was abnormal before antibiotics were given. 2) Vancomycin and metronidazole did not cure her colitis. 3) Remission was obtained by the treatment for ulcerative colitis. The association of ulcerative colitis and Basedow's disease and the meaning of clostridium difficile in ulcerative colitis were reviewed and discussed.
