1987 Volume 29 Issue 1 Pages 16-22
The endoscopic examination was performed in 136 patients at Tokyo University Hospital and endoscopic biopsy specimens were obtained from both the greater curvature of the middle body and the lesser curvature of the middle antrum, processed for both histologic examination and pepsinogen I (PG I), pepsinogen II (PG II) measurement. The concentrations of PG I and PG II in 1 mg wet weight of the mucosa were determined by radioimmunoassays as reported previously (Clip. Chim. Acta 122 : 61 and 126: 85, 1982). The results were obtained as follows: 1) Compared with the endoscopically normal cases (n: 34), the PG I and PG I levels of the mucosa in gastric ulcer cases (n: 40) showed slightly lower values but there were no significant differences between the two groups. In the duodenal ulcer cases (n: 26), there was a significantly high value of the PG I level of corpus mucosa (CPG I) and a tendency of high values both in the PG II level of corpus mucosa (CPG II) and the PG II level of antral mucosa (APG II). In gastric carcinoma cases (n: 18), there were significantly low values both in the levels of CPG I and CPG II, and a tendency of low value in the level of APG II. 2) Both levels of mucosa PG I and PG II decreased gradually according to the progress or severity of both the atrophic gastritis and intestinal metaplasia.
