GASTRIC MUCOSAL BLOOD FLOW IN ACUTE PANCREATITIS OF DOGS

Abstract

Gastrointestinal bleeding is frequently observed as one of severe complications in hemorrhagic necrotizing pancreatitis. As a defence mechanism gastric mucosal blood flow was investigated in experimental acute pancreatitis of dogs. Acute pancreatitis was induced by bile and trypsin injection into the pancreatic duct of 10 dogs and gastric mucosal blood flow was endoscopically measured by hydrogen gas generated by electrolysis as previously reported elsewhere. Hemorrhagic necrotizing pancreatitis and much bloody ascites were observed macro -and microscopically at 5 hours after induction of pancreatitis but acute gastric mucosal lesions such as erosion or gastric ulcer were not detected throughout the experiments. However, gastric mucosal blood flow showed a trend for decrease during the experiments of 3 to 5 hours and at the same time the reddness of gastric mucosa was gradually getting pale. This study suggests that there are some influences of decreased gastric mucosal blood flow on gastric mucosal damage in acute pancreatitis of dogs.