THE INCIDENCE OF MUCOSAL LESIONS OF GASTRODUODENUM IN CIRRHOTICS

-IN COMPARISON WITH HEPATIC FUNCTIONAL RESERVE CAPACITY-

Abstract

The aim of our study was to elucidate the relationship between the development of mucosal lesions of gastroduodenum and hepatic function in cirrhotics especially from the point of view of hepatic functional reserve capacity. Gastroduodenal lesions occurred frequently in cirrhotics (redness of gastric mucosa and gastric erosion ; 46.3%, gastric ulcer ; 20.0%, duodenal ulcer ; 4.8%). Redness of gastric mucosa and gastric erosion were most frequently noted on gastric corpus, and gastric ulcer was found more frequently on gastric angle and corpus than any other parts of stomach. Furthermore, in 13 cases (8.1%) of 160 patients with liver cirrhosis, gastroduodenal lesions caused gastroduodenal bleeding. In tests of hepatic functional reserve capacity and, serum cholinesterase, serum albumin, hepaplastin test and ICG Rmax were significantly lower in cirrhotics with gastroduodenal lesions than those in cirrhotics without gastroduodenal lesions, whereas prothrombin time was longer and 2hr value of serum bile acids by endogenous bile acid loading test were significantly higher in cirrhotics with gastroduodenal lesions than those in cirrhotics without gastroduodenal lesions. Besides, 15 min retention rate of ICG and 15 min ΔcAMP of glucagon loading test were worse in cirrhotics with gastroduodenal lesions. From these results, it is suggested that development of gastroduodenal lesions should be taken into consideration in cirrhotics with diminution of hepatic functional reserve capacity.