EXPERIMENTAL STUDY ON THE EFFECTS OF LOCAL INJECTION OF AETHOXYSRLEROL FOR GASTRIC MUCOSA WITH SPECIAL REFERENCE TO THE SUBMUCOSAL ARTERIAL PLEXUS

Abstract

We studied on the effect of local injection of Aethoxysklerol (AS) for gastric wall, especially, on the submucosal arterial plexus in 33 mongrel dogs. Microangiography was performed in order to observe the course of the gastric submucosal vessels after injection of AS. Soon after injection of AS, marked edema appeared in the submucosal layer and an avascular area in microangiography was formed in the same extent. After 3 days, inflammatory cell infiltration was noted in the submucosal layer, and after 7 days, vasculitis and thrombus appeared extensively in the submucosal layer. The extent of the avascular area in microangiography after 7 days was little less than it of the avascular area which was formed first. After 14 days, fibrosis and organization of the arteries were formed in the submucosal layer, and the avascular area reduced slightly in the size. This study suggested that local injection of AS would be an effective method for emergent endoscopic hemostasis of acute hemorrhagic gastric ulcer and be useful for preventing the rebleeding.