BASIC EVALUATION OF CYANOACRYLATE ON LEIN (THE SECOND REPORT)

LONG-TERM EFFECTS AND THE COMBINATION OF CYANOACRYLATE AND LIPIODOL

Abstract

The influence of Cyanoacrylate and combined administration with Lipiodol in rabbit vein was studied basically. 1) Histological changes were observed 1, 3, and 9 months after injection of cyanoacrylate into the ear vein of rabbits. Cyanoacrylate produces foreign body reactions and was retained in the rabbits vein for a long term. 2) On the rapid injection of Cyanoacrylate into the inferior vena cava of rabbits (venous pressure : 6cmH2 O) polymerized coagulation was recognized instantaneously, but no adverse effects to the heart and lungs were recognized. 3) Coagulation was seen over a length of about 8cm when Cyanoacrylate was injected into the inferior vena cava of rabbits for about 3 sec. 4) The mixture of Cyanoacrylate and Lipiodol (1:1) got to the lungs via the heart when it was injected into the inferior vena cava. These findings indicate that cyanoacrylate, when used alone, obstructs the blood vessels for a long term, and it is unlikely to become a thrombotic substance when injected rapidly. However, it may migrate through the blood vessels and may obstruct the blood vessels in other organs when it is administered in combination with lipiodol.