Abstract
A 59-year-old man was admitted to our hospital with the complaints of general fatigue, anorexia, body weight loss, and deformity of finger nails. Diarrhea and pigmenta-tion of skin were not observed. X-ray and endoscopic examination showed multiple polyposis and hypertrophic change in the stomach. However, polyposis was not seen in the colon, only a few small polyps were recognized. Biopsy of gastric polyps revealed hyperplasia of foveola epithelium, cystic dilatation of glands, edema, and inflammatory cell infiltration in lamina propria. Based on these findings, this case was diagnosed as the "incomplete type" of Cronkhite-Canada syndrome. Although prednisolone was administer-ed at 30mg per day for one month and there was no effective change in endoscopic findings and hypoproteinemia. Then antiplasmin agent (T-AMCHA, 750 mg per day) and H2 blocker (voxatidine acetate hydrocloride, 150mg per day) were given, and clinical and laboratory abnormalities improved gradually. It has been considered that steroid is an effective therapeutic agent for Cronkhite-Canada syndrome, but ineffective case have been reported so far in the literature except our case. Therefore it would be necessary to reevaluate the effectivity of steroid in Cronkhite-Canada syndrome and to find more potent therapeutic approach for this disease.
