1992 Volume 34 Issue 11 Pages 2559-2564
The tumor-localizing abilities of Gallium porphyrin complex (ATX-70) were assessed by means of high performance liquid chromatography. We used two kinds of tumors; one was transplanted tumor of human pancreatic carcinoma to BALB/cnu nude mice and the other experimental pancreatic carcinoma of golden hamsters induced by N-nitroso-bis-(2-oxypropyl) amine (BOP). In cases of nude mice, the concentration of ATX-70 was measured in tumor, liver, kidney, lung and skin at 6, 12, 24 and 48 hours after administration of 25mg/kg body weight of ATX-70 intraperitoneally (I.P.). On the other hand, in cases of golden hamsters, the concentration of it were measured in pancreatic carcinoma, liver, kidney, lung and normal pancreatic tissue, at 24 and 48 hours after administration of 10mg/kg body weight intraperitoneally and 3mg/kg body weight intravenously (I. V.). The results were as follows; 1) nude mice: The concentration of ATX-70 in tumor was 73.3±14.0 mg/kg (Acetone powder weight) and showed its peak level at 24 hours after administration. The concentration of ATX-70 in tumor was higher than it of skin or lung at 24 hours after administration. 2) golden hamsters: The concentration of ATX-70 in pancreatic carcinoma was 326±109mg/kg at 24 hours after administration of it I.P. and much higher than that of normal pancreatic tissue, kidney or lung. The concentrations of ATX-70 in tumor and other organs also showed almost same results after intravenous administration of it. These results suggest that ATX-70 may be useful as one of photosensitizers for photodynamic therapy.
