1992 Volume 34 Issue 7 Pages 1564-1568
390 cases with duodenal ulcer (DU) detected by gastric mass survey over 40 years of age were followed up for 2 years with endoscopy every 6 months and without any anti-ulcer drugs. In the same group, 300 cases without DU were selected as the healthy controls. Serum pepsinogen (PG) I and II were measured at the end of the follow-up period in the DU cases. Serum PG I were 69.7± 1.4 ng/ml in the DU cases and 57.7± 1.6 ng/ml in the controls (p<0.0001). Regarding the relation between ulcer activity during the follow-up period and PG I, PG I in DU which remained in the scar stage was significantly less than PG I in active DU. Also PG I in linear and multiple DU was significantly higher than PG I in single DU. These data suggest that cases with high serum PG I are not only in high risk of DU, but anticipated to take active course.
