CHOLANGIOGRAPHIC STUDY BY ERC AFTER INTRAARTERIAL INFUSION CHEMOTHERAPY AND TRANSCATHETER ARTERIAL EMBOLIZATION IN PATIENTS WITH HEPATOCELLULAR CARCINOMA

Abstract

We performed ERC in 10 patients with hepatocellular carcinoma after intraarterial infusion chemotherapy and transcatheter arterial embolization. Extensive and severe bile duct necrosis was recognized in 3 patients. Cholangiographic characteristic was irregular stenosis of the bile duct in hepatic portion to peripheral bile duct and it resembles primary sclerosing cholangitis. These 3 cases complicated gallbladder necrosis and hepatic infarction. In one case bile duct necrosis occurred only after CDDP infusion, and thrombosis of intralobular artery was seen in pathological study. These results indicated that ischemia due to anticancer drug-induced intravasucular thrombosis cause bile duct necrosis.