Abstract
A 25-year-old woman was consulted to our hospital complaining of epigastric pain. Laboratory data showed hypoproteinemia. Upper gastrointestinal endoscopic examination revealed enlarged gastric folds and multiple nodular lesions covered by white coat in the body and fornix of the stomach, consistent with diffuse varioliform gastritis. After administration of lansoprazole, epigastric pain was improved but hypoproteinemia continued. Helicobacter pylori was positive by culture of the gastric mucosa. We diagnosed hypertrophic lymphocytic gastritis associated with protein-losing gastropathy according to histological and endoscopic examination of the stomach. After getting the informed consent, eradication therapy of Helicobacter pylori was performed. Then, serum total protein was normalized and abnormal findings of endoscopic and histological examination of the stomach was improved. Lymphocytic gastritis is a histological entity characterized by diffuse infiltration of small lymphocytes into the surface and foveolar gastric epith-elium. There are a few case reports of lymphocytic gastritis in Japan.
