A CASE REPORT OF ADVANCED GASTRIC CANCER ASSOCIATED WITH ACANTHOSIS NIGRICANS AND DIFFUSE ESOPHAGEAL PROTRUDED LESIONS

Abstract

A 65-year-old man was admitted to our hospital because of dark skin pigmentation and papillomatous changes of the whole body. The diffuse protruded lesions were noted on the face, hands, feet, inguina, and axillae. The skin lesion was typical of acanthosis nigricans which was comfirmed histologically as hyperkeratosis, papillomatosis and pigmentation of basal layer on skin biopsy. Endoscopic examinations revealed advanced gastric cancer at the body and numerous protruded granular changes of the esophageal mucosa. The biopsy specimen from the esophagus revealed epithelial hyperplasia. Because the cervical lymph nodes metastases were positive, the chemotherapy was performed, and skin lesions and gastric cancer were improved. As malignant acanthosis nigricans with esophageal lesions is relatively rare, we reported a case and reviewed the literature.