Abstract
A 65-year-old man visited our hospital because of his epigastralgia and abdominal fullness. Endoscopic examination revealed a whitish papillary lesion with swollen mucosa of the duodenum. He was diagnosed as follicular lymphoma (grade I, stage IE) based on the immunohistochemical staining of the biopsied specimen. He was treated by anti-CD20 antibody (Rituximab). Two months after the treatment, endoscopic examination revealed the shrinkage of the duodenal tumor, indicating that the treatment of anti-CD20 antibody was very effective as a non-invasive therapy.