TWO CASES OF ADVANCED COLORECTAL CANCERS HAD DIFFERENT INFILTRATION EACH LAYER UNDER SUBMUCOSA

Abstract

We report two cases of advanced colorectal cancers had different infiltration each layer under submucosa. One was a 63-year-old female in the rectum, and the other was a 72-year-old female in the acending colon. Barium-enema, colonoscopy, and echo-endoscopy showed cancer lesion resembling a submucosal tumor (SMT). On pathology both lesion were found to be de-novo well-differentiated adenocarcinoma located in the mucosa. In the first case the poorly differentiated adenocarcinoma was found to have infiltrated from the submucosa to the subserosa ; there was evidence of severe fibrosis and lymphocytic infiltration. The second case had a moderately-differentiated adenocarcinoma with fibrotic changes from the submucosa to subserosa ; which was poorly-differentiated at the subserosa. Both cases had infiltrating cancerous lesions that resembled SMT. The 49 cases of colorectal cancers resembling SMT reported in Japan we reviewed.