Comparative Assessment of the Effect of Solanine Administered Orally and Intraperitoneally on Hepatic Dysfunction in Male Rats

Abstract

An oral dose of 250 mg/kg of solanine did not alter the activities of serum glutamic oxalacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and serum cholinesterase (ChE) in male rats 24 hr following the treatment. However, i.p. administered solanine (20 mg/kg) significantly increased the levels of SGOT and SGPT, and decreased the activities of ChE and microsomal enzymes, including cytochrome P-450, suggesting ingested solanine is several times less hepatotoxic than i.p. administered solanine, probably due to its poor absorption from the stomach.