Abstract
Retroperitoneal infection is a secondary infection caused by inflammation, injury, and perforation of organs adjacent to the retroperitoneum, and early detection and drainage are important. Sometimes the infection spreads beyond the boundaries of clinical departments, and it can become an intractable condition that requires treatment in multiple clinical departments. In this study, we treated such intractable retroperitoneal infection with CLAP (continuous local antibiotics perfusion), which is a treatment method for bone and joint infections, and obtained favorable results. Case 1 was a huge retroperitoneal abscess arising from a renal abscess and reaching the thigh. Case 2 was a retroperitoneal abscess of unknown cause that relapsed due to sepsis despite percutaneous drainage. In all cases, highly invasive surgery was considered necessary, but the use of CLAP enabled relatively minimally invasive infection control. The treatment principles of CLAP are 5D (Detection, Design, Defense of the tissue, Do thoroughly, Disappearance of signs of infection). Similar to bone and joint infections, CLAP for retroperitoneal infections based on 5D is expected to provide effective drainage and high local antibacterial drug concentration, resulting in infection control. CLAP is effective for various deep infections, and may fill gaps in clinical departments.
