Hyperkinetic Heart Syndrome in The Aged Hypertensives
1979 Volume 16 Issue 1 Pages 29-37
Details
1979 Volume 16 Issue 1 Pages 29-37
The hemodynamic and clinical characteristics of 21 hypertensive patients with high cardiac index of 4.0L/min/M2 or more (HH, mean age 72.5y) have been studied in comparison with those of 21 hypertensive patients with normal cardiac output (NH, 74.3y) and 17 cases of normotensive aged control (NT, 75.1y). Mean values of cardiac index in each group were 4.57, 2.85 and 2.72L/min/M2, respectively. Although there was no significant difference in blood pressure between HH and NH, heart rate of 86.6/min and stroke index of 54.2ml/beat/M2 in HH were significantly higher than those of NH and NT (p<0.02). Morevoer, total peripheral resistance in HH was significantly lower and appearance time was shorter than those of the other two groups (p<0.02).
Increase in cardiac index after intravenous administration of isoproterenol in HH was 1.92±0.26L/min/M2 (mean±S.E.), which was significantly larger than those of NH and NT (p<0.05). Hypertensive complications in HH, accordng to the criteria of Hypertensive Committee of Tokyo University, were less than those of NH. There were no significant difference in hemoglobin. T3-RUS, plasma renin activity and total plasma volume between HH and NH.
Antihypertensive effect of oral beta adrenergic blockade with propranolol or oxprenolol was evaluated in 9 cases of HH. Treatment of 12 weeks resulted in a reduction of 14mmHg in systolic and 10mmHg in diastolic pressure with a remarkable reduction of heart rate.
It was concluded that there were a few aged hypertensive patients with hyperkinetic heart syndrome, which has been observed in younger hypertensives. They had a hyperresponsiveness to Isoproterenol and beta adrenergic blockade was effective in reduction of their high blood pressure.
Hypertensive complication in these patients were mild.
