Abstract
In 1943, Seizo Katsunuma, Ujihiro Murakami and Masatoki Tateno made a report of hemophilia combined with color-blindness, and the pedigree concerned. We have since seen another instance. This was found in the west district of Nagoya City.
The proband is a male of the fourth generation who had hemophilia with normal color sense and died of hemorrhage of abdominal organs in 1944 at the age of 32. In the same generation, four of his cousins were victims ...... two died of hemophilia, one is color-blind and the other is hemophilia combined with deuteranopia. In the third generation of the pedigree were two double conductors, one death from hemophilia and one color-blind. Their mother was also a double conductor.
The female of the first generation had an illegitimate girl besides those children with her husband. Nothing particular is seen in the girl descendants. Most likely the double conductor lasted for two generations and the two genes have crossed over.
This is the first instance of pedigree ever found in Japan, in which crossing- over seems to have occurred.
