Abstract
The anti-C agglutinin in human normal serum of group O appears at a rate of 6.7±0.8 per cent in the population. Examination of families showed that this irregular agglutinin is inherited as a simple Mendelian recessive. From the nature that the antigen C is common between agglutinogens A and B, the agglutinogen C is obviously inherited as a simple Mendelian dominant, the gene for which being completely linked with the genes for A and B. In order to ascertain the genetical relations between the formation of antigen and that of antibody, further investigation is necessary.