EFFECT OF ACETAMIDE ON THE MITOTIC RATE IN EHRLICH ASCITES TUMOR
1976 年 51 巻 1 号 p. 53-58
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1976 年 51 巻 1 号 p. 53-58
The effect of acetamide and certain antibiotics on the multiplication of the Ehrlich ascites tumor cells in mice was examined. The acetamide had a marked effect on increasing the mitotic rate of the EAT cells. However, mitomycin-C or nitromine had a strong inhibitory effect on the multiplication of the cells. In contrast the rate of cell multiplication in acetamide-mitomycin-C or nitromine mixture showed no effect what so ever. The acetamide appeared to counteract either mitomycin-C or nitromine on the metabolic process of the multiplication of EAT cell.
The mode of the action on EAT cells by these two groups of chemicals was similar to that on the facet-formation in Drosophila. The acid amides not only are specific to the eye development in Drosophila, but also considerably increase the mitotic rate of EAT cells in the mouse.
