MUTAGENICITY OF ANTIMICROBIAL MEDICINE CONTAINING ACETYLFURATRIZINE

Abstract

The biological effects of panfuran-troche containing acetylfuratrizine were investigated. λ phages were induced from both Escherichia coli W3110(λ) and W3110(λind^S). Radiosensitive mutants, E. coli NG30 and Hs30R were more sensitive for killing than the wild-type, H/r30R, to this medicine. Revertants (argF^-→argF⁺) were detected in both H/r30R and Hs30R(uvrA^-), but in NG30(recA^-). The mutation frequency was much significant in Hs30R in comparison with that of H/r30R.