Studies on chemical induction of chromosomal aberrations in postcopulation germ cells and zygotes of female mice
II. Induction of heritable translocations
1983 年 58 巻 4 号 p. 353-359
詳細
1983 年 58 巻 4 号 p. 353-359
The induction of heritable translocations with chemicals in postcopulation germ cells of female mice was investigated. In the methyl methanesulfonate (MMS)-treated group (100mg/kg), 14 partially sterile and 5 sterile males out of 118 F1 male progeny were found. In contrast, in the mitomycin C (MC)- treated group (3mg/kg and 4mg/kg) the frequencies were low. These results indicate that the yield of heritable translocations parallels the formation of chromosome-type aberrations at the first cleavage reported previously.
