抄録
The effects of several DNA damaging agents on cell differentiation and morphogenesis were investigated using a radiation sensitive mutant (γs-13) and the wild-type strain (NC-4) of a lower eukaryote, Dictyostelium discoideum. When furylfuramide, mitomycin C or methylmethanesulfonate was present during the course of cell differentiation from amoebae to spores, abnormally shaped fruiting bodies, most of which were double fruiting bodies, were induced at a high frequency in γs-13 when compared with NC-4. In addition, the number of produced spores was largely depressed in γs-13 by the presence of those agents during differentiation. Furthermore, many of the spores were inviable, especially at higher concentrations. In NC-4, on the contrary, almost all of the formed spores were viable at the various concentrations tested.
