SHORT PAPER Cobalt (II) salt-quinoline compound interaction: combined mutagenic activity in Salmonella typhimurium and strength of coordinate bond in the mixtures

Abstract

The mutagenic activity of cobalt (II) chloride (CoCl₂) was examined using the Salmonella test system in the presence of quinoline compounds. CoCl₂, which itself is non-mutagenic, exhibited mutagenicity when combined with quinoline, 2-methylquinoline, 3-methylquinoline, 4-methylquinoline, 6-methylquinoline, 7-methylquinoline, 2-aminoquinoline, 4-aminoquinoline and 8- aminoquinoline in strains TA1537 and TA2637. Mixtures of CoCl₂ and 8- methylquinoline, 3-aminoquinoline or 5-aminoquinoline did not induce mutations. The combined mutagenicity may be due to a formation of complexes between the Co(II) cation and quinoline compounds judging from the spectral data.