Environmental Factor Dependent Maximum Likelihood Method for Association Study Targeted to Personalized Medicine

Abstract

The most challenging strategy for analyzing genome-wide polymorphisms and/or expression profiles is to solve multi-factor causal-relationship simultaneously. As the first step, we propose a framework of association study using maximum likelihood method that simultaneously handles genetic polymorphisms and epi-genetic information, e. g. environmental factors. We evaluate the theory by applying it to genotyped data of myocardial infarction (MI) patients.