Genome Informatics
Online ISSN : 2185-842X
Print ISSN : 0919-9454
ISSN-L : 0919-9454
Using Analogical Reasoning to Predict a Protein Structure
Takashi IshikawaTakao Terano
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JOURNAL FREE ACCESS

1993 Volume 4 Pages 339-346

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Abstract
This paper describes a computational method to predict a protein structure by analogical reasoning from known protein structures. The proposed method: Analogy by Abstraction uses heuristics to reduce the search complexity to get appropriate transformations to create a structure of the unknown protein form a known protein structure. We implement an algorithm of the method in Prolog programing language, and exemplify its effectiveness by re-predicting the structure of ‘Zinc fingers’ from its amino-acid sequence.
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© Japanese Society for Bioinformatics
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