Using Analogical Reasoning to Predict a Protein Structure

抄録

This paper describes a computational method to predict a protein structure by analogical reasoning from known protein structures. The proposed method: Analogy by Abstraction uses heuristics to reduce the search complexity to get appropriate transformations to create a structure of the unknown protein form a known protein structure. We implement an algorithm of the method in Prolog programing language, and exemplify its effectiveness by re-predicting the structure of ‘Zinc fingers’ from its amino-acid sequence.