抄録
We have been developing a novel method of deriving a score function for protein threading. In this method, the constraint that the score of the native threading is minimum over all possible threadings is expressed in a form of linear inequalities, and then parameters defining a score function are determined by solving these inequalities. The proposed method was evaluated using Lathrop and Smith's algorithm for finding optimal threadings and was shown to be effective for computing nearly correct threadings.
