The development of the cubic anvil type high pressure apparatus made it possible to perform powder X-ray diffraction study under wide range of pressure and temperature. By combining with an energy dispersive type X-ray diffraction system, the exposure time has been reduced considerably and the kinetics of the pressure-induced phase transformation can be studied. Diamond anvil cells contributed a lot to extend the pressure range of high pressure X-ray studies. It is now possible to study the structure and the compressibility of powder materials up to megabar region. Many new phase transformations in simple oxides have been found using diamond anvil cells.