Effects of Oral Sodium or Potassium Administration on Serum Urate Concentration and Urinary Urate Excretion in Japanese Young Athletes

Abstract

Changes in serum urate concentration (S-UA), urine flow (U_flow) and urinary urate excretion rate (U_UA) after sodium (Na)or potassium (K) administration were detected in Japanese young athletes. Subjects (n=11, male,19-22 yrs) drank 500 ml of 0.6%saline (Na solution) or 1.2% potassium gluconate (K solution)within 10 minutes after more than ten hours' overnight fasting and water depletion. Experimental temperature was 23±2°C, and the humidity was 40-65%.
S-UA, U_flow, urinary urate (cU_UA), Na (cU_Na), K (cU_K) concentrations and creatinine clearance (C_cr) were measured throughout the experiment, from one hour before till five hours after drinking.