The influences of steroid hormone on the uric acid metabolism were evaluated by measuring serum and urine uric acid, uric acid clearance (Cua) and uric acid creatinine clearance ratio (Cua/ Ccr) in 10 control subjects and 14 patients being treated with prednisolone.
In patients being treated with prednisolone, serum uric acid was 3.8=E0.9mg/d1 (mean: LSD), urine uric acid was 3917E139mg/day, Cua was 7.49±2.67m1/min and Cua/Ccr was 12.7±4.8%.
In control subjects, serum uric acid was 5.5±0.9mg/d1, urine uric acid was 361±146mg/day, Cua was 4.30±1.95m1/min and Cua/ Ccr was 8.5±2.9%.
There were significant differences in serum uric acid (P0.01), Cua (P<0.05) and Cua/Ccr (P<0.05) between patients being treated with prednisolone and control subjects, but no significant differences in urine uric acid.
Serum uric acid significantly more decreased (P<0.05) and Cua and Cua/Ccr significantly more increased (P<0.01) in patients after treated than in before treated.
These results indicate that prednisolone may decrease the production of uric acid and may increase the renal clearance of uric acid.
View full abstract