Abstract
In patients with hyperuricemia, gouty attacks are induced by rapid changes in serum uric acid (UA)levels. One of the cause of the rapid increase in serum UA level is a hyperpurine diet such as alcohol intake. We present here an unique experimental data showing that Kremezin, which is widely used to reduce the serum creatinine level by absorbing creatinine in the intestine to prevent the development of renal failure, is useful to reduce the serum uric acid (UA) level. First, we studied the effect of Kremezin in an animal model. We used rats with oral inosine load test after injection of the anti-uricase compound oxonic acid (OA). Kremezin was given orally just before the loading with inosine-containing food. Kremezin reduced the elevation of serum uric acid. Kremezin could absorb not only inosine but also other purine bases in vitro (e. g. inosine: 98.6%, purine: 99.3%, adenine: 96.5%, adenosine: 98.3%, guanosine: 99.1%, etc). Next, we studied the effect of Kremezin on the increase in serum UA concentration in healthy volunteers after drinking beer (1L in 10 min.). One hour after taking beer, blood samples were taken and UA concentrations were determined. Kremezin reduced the increase in serum UA levels compared with that in those who took beer without premedication (control). Based on these findings, we suggest that Kremezin might be useful to stabilize the serum UA levels by absorbing purine bases in alcoholic beverage as well as in foods. Therefore Kremezin is an alternatives trategy to reduce the increased risk of gout following alcohol intake.
