Abstract
To identify gender-specific factors associating with serum uric acid concentration, we examined a healthy population composing of 337 of males and 117 of females who visited the division of medical examination in our hospital in 2002. The healthy population was defined as healthy subjects without any medical treatment for hyperlipidemia, hypertension, diabetes mellitus or hyperuricemia, whose age, sUA and serum creatinine in male and female subjects were 51+11,48+12 years old and 5.8+1.3,4.2+1.0 mg/d l, and 0.8+0.1,0.6+0.1 mg/dl, respectively. The association of all laboratory data with serum uric acid was evaluated by the linear regression analysis in male and female subjects. Serum uric acid was significantly correlated with sCr, logTG and systolic blood pressure in both gender. There was a gender-specific significant correlation between sUA and BMI in male subjects or value of Ht in female subjects. Using multiple regression analysis, sUA independently correlated with creatinine, logTG and Ht in female subjects, where 50% of total variation in sUA accounted for these independent variables. In conclusion, Ht was an independent female-specific factor associated with sUA.
