Release of beta-Lactoglobulin Adsorbed on Octacalcium Phosphate and its Hydrolyzates.

Takashi Kumagai; Takahisa Anada; Hidetoshi Shimauchi; Osamu Suzuki

doi:10.14832/gsjsdmd.2007f.0.11.0

50th General Session of the Japanese Society for Dental Materials and Devices in conjunction with International Dental Materials Congress 2007

Session ID : PS-03

DOI https://doi.org/10.14832/gsjsdmd.2007f.0.11.0

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Host: The Japanese Society for Dental Materials and Devices

Poster Presentation Competition

Release of beta-Lactoglobulin Adsorbed on Octacalcium Phosphate and its Hydrolyzates.

*Takashi Kumagai, Takahisa Anada, Hidetoshi Shimauchi, Osamu Suzuki

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Keywords: octacalcium phosphate, beta-Lactoglobulin, control release

CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

The present study was designed to investigate whether the hydrolysis of octacalcium phosphate (OCP) affects the release of beta-lactoglobulin (beta-Lg) adsorbed on OCP and its hydrolyzed apatitic products (OCP hydrolyzates). The release of beta-Lg at pH 4.0 tended to be inhibited with the advancement of hydrolysis from OCP into apatite. The previous studies reported that OCP can be converted to apatite and is subjected to osteoclastic resorption when implanted in bone. The tendency of the protein desorption from OCP and its hydrolyztaes at acidic pH suggests that these calcium phosphates may be used as carrier of cytokines in bone tissue engineering by OCP.

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