In vitro biocompatibility with osteoblast-like cell on zirconia

Abstract

The origin of the interest in using zirconia as a ceramic biomaterial was its good chemical and dimensional stability, its mechanical strength and toughness, coupled with a Young's modulus in the same order of magunitude of stainless steel alloys. It was introduced into medicine and dentistry as an ideal replacement for metal. There are various types of zirconia for biomaterial applications. Among them, Ce-TZP/Al₂O₃ nanocomposite was developed to have a high fracture toughness and an excellent durabillty against low temprature degradation. We have been studying on the Ce-TZP/Al₂O₃ nanocomposite as dental restoration. The aim of this study was to investigate the biocompatibility with osteoblast-like cell on the surface of two kinds of zirconia ceramics (Ce-TZP/Al₂O₃ nanocomposite and a conventional Y-TZP) in comparison to titanium.