Abstract
Recombinant human BMP-2 was combined with FRIOS Algipore, calcified algae-derived porous hydroxyapatite, and was applied to direct pulp capping in rats. Reparative dentin formation induced by the composite was analyzed, compared with calcium hydroxide having been used conventionally. The composite formed quantities of thick reparative dentin that has dentinal tubules. Moreover, the composite induced reparative dentin formation without the formation of necrosis layer underneath it, indicating that it is a bio-compatible material for dentin formation.