Effects of mats with "A Distinctive 4-Layer 3-Dimensional Structure" on sleep quality, skin function, and fatigue: A non-controlled open-label study.

抄録

Purpose: Results of previous studies suggest that improved sleep quality improves the secretion of growth hormone/insulin-like growth factor-I (IGF-I) and melatonin. In this study, we verified the effects of a mattress with “A Distinctive 4-Layer 3D Structure” as the study product, on sleep quality, skin quality, and fatigue, through a non-controlled open-label study. Method: 12 women (age 50.1 ± 4.9 years) with strong subjective and objective findings were selected from among 33 women who were dissatisfied with sleep and skin quality. A non-controlled open-label study was conducted for changes in physical information when the study product was used for 8 weeks. The study product was provided by Nishikawa Co., Ltd. (Chuo-ku, Tokyo). Pittsburgh Sleep Quality Index (PSQI-J), Anti-Aging QOL Common Questionnaire (AAQol), verification of subjective symptoms using Visual Analogue Scale (VAS), anthropometric measurements, skin moisture, transepidermal water loss (TEWL), skin viscoelasticity, and blood biochemistry tests were conducted before the commencement of the study and at 4 and 8 weeks after the start of the study. This study was conducted with the approval of the ethics review committee. Results: PSQI-J showed a significant improvement in sleep quality, time to fall asleep, difficulty sleeping, and daytime difficulty waking, 8 weeks after the start of the study. The PSQI global score improved significantly from 8.2 ± 1.4 to 4.2 ± 2.2 (p < 0.01). AAQoL and VAS also showed a significant improvement in symptoms related to sleep and fatigue. For skin quality (upper arm), the skin moisture increased significantly after 8 weeks (+35.9%, p < 0.05), and reactivity of TEWL also increased (+16.9%, p < 0.01). The skin viscoelasticity index R2 increased significantly after 8 weeks (p < 0.05). Conclusion: Improvements in subjective symptoms related to sleep and fatigue and improvement in skin quality (moisture and viscoelasticity) were observed with the use of the study product, suggesting that the improvement in sleep quality may also contribute to cosmetic effects.