An Autopsy Case of Bronchogenic Carcinoma with the Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Abstract

A 44 year-old man admitted for the evaluation of nausea and anorexia of four weeks' duration, and was diagnosed as having bronchogenic carcinoma with the syndrome of inappropriate secretion of antidiuretic hormone.
The tumor tissue obtained at autopsy had a significant level of antidiuretic hormone like activity.
Histological diagnosis was oat cell carcinoma, and electron microscopic study showed secretory granule-like structure in the cytoplasma of tumor cells.