Abstract
We performed bronchial arterial infusion (BAI) of 50 mg cisplatin in eight lung cancer patients. Postoperatively the platinum concentration in the tumor (average: 11.5 microgram/g·tissue) was more than twice the concentration in the normal lung tissue in five resected cases. We also detected high serum concentrations of active cisplatin (over 3 microgram/ml) during arterial infusion. It was considered that the concentration of active cisplatin in bronchial artery blood sufficiently reached the tumor inhibition dose level for adenocarcinoma of the lung.
In conclusion, because of the improvement of cisplatin transport to the tumor, BAI of cisplatin for lung cancer should be an effective local therapy.
