1988 Volume 28 Issue 7 Pages 901-905
A 64-year-old male case of lung cancer producing α-fetoprotein (AFP) was reported. Chest X-ray film revealed a large round mass lesion in the right upper lung field. Percutaneous lung biopsy revealed poorly differentiated adenocarcinoma. Although the serum concentration of AFP was 20, 500 ng/ml, there was no evidence of tumor mass in the liver or other digestive organs by CT and ultrasonography. Right upper lobectomy after radiation therapy was performed. It was strongly suggested that the lung tumor produced AFP because the serum AFP level decreased with treatment. Production of AFP by lung cancer cell was confirmed by an immunoenzyme labelling technique using PAP. There have been only ten cases of production of AFP by lung cancer cells in Japan.
